In ovo hepatocarcinogenicity of N-nitrosodimethylamine and N-nitrosodimethylamine in White Leghorn chickens
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چکیده
منابع مشابه
N-Nitrosodimethylamine Carcinogenesis in Nicotinamide-deficient Rats1
Special diets that were extremely low in protein (5.5%) and high in carbohydrate were used to test the effect of nicotinamide on A/-nitrosodimethylamine-induced Carcinogenesis in Holtzman albino rats. The level of nicotinamide in the three diets ranged from 0 mg/kg of food to 50 mg/kg to 500 mg/kg. During the treatment with these diets (5 weeks) and the carcinogen (18 days), the renal and hepat...
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.................................................................................................................................. iii ACKNOWLEDGEMENTS ............................................................................................................ v LIST OF TABLES ..........................................................................................................................
متن کاملMetabolic denitrosation of N-nitrosodimethylamine in vivo in the rat.
Enzymatic denitrosation is a potentially inactivating metabolic route that has been shown to convert carcinogenic N-nitrosodimethylamine (NDMA) to methylamine (MA) in vitro. To investigate its quantitative course in vivo, groups of 8-week-old male Fischer rats have been given small (8-15 mumol/kg) p.o. or i.v. bolus doses of 14C-labeled NDMA and the subsequent formation of radioactive MA has be...
متن کاملAttenuation of N-nitrosodimethylamine induced hepatotoxicity by Operculina turpethum in Swiss Albino mice
Objective(s): To appraise the antihepatotoxic efficacy of ethanolic extract of Operculum turpethum root on the liver of Swiss albino mice. Materials and Methods: Hepatic fibrosis was induced in adult male albino mice through intraperitoneal administrations of N-nitrosodimethylamine (NDMA) at the concentration of 10 mg/kg body weight. The liver toxicity and therapeutic effect of the ...
متن کاملInhibition of N-nitrosodimethylamine metabolism in rats by ether anesthesia.
Short-term exposure to diethyl ether strongly inhibits the metabolism of N-nitrosodimethylamine (NDMA). Twenty-six 6-week-old male Fischer 344 rats were exposed to ether vapor until their righting reflex was lost (approximately 2 min). The animals were removed from the ether and NDMA was immediately administered by i.v. bolus injection at a dose of 300 microgram/kg via a cannula surgically inse...
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ژورنال
عنوان ژورنال: Journal of the Hellenic Veterinary Medical Society
سال: 2018
ISSN: 2585-3724,1792-2720
DOI: 10.12681/jhvms.18884